Unusual
Features of the SARS-CoV-2 Genome Suggesting Sophisticated Laboratory
Modification Rather Than Natural Evolution and Delineation of Its Probable
Synthetic Route
Yan, Li-Meng; Kang, Shu; Guan, Jie; Hu, Shanchang
COVID-19 pandemic caused by the novel coronavirus SARS-CoV-2 has led to
over 910,000 deaths worldwide and unprecedented decimation of the global
economy. Despite its tremendous impact, the origin of SARS-CoV-2 has remained
mysterious and controversial. The natural origin theory, although widely
accepted, lacks substantial support. The alternative theory that the virus may
have come from a research laboratory is, however, strictly censored on
peer-reviewed scientific journals. Nonetheless, SARS-CoV-2 shows biological
characteristics that are inconsistent with a naturally occurring, zoonotic
virus. In this report, we describe the genomic, structural, medical, and
literature evidence, which, when considered together, strongly contradicts the
natural origin theory. The evidence shows that SARS-CoV-2 should be a
laboratory product created by using bat coronaviruses ZC45 and/or ZXC21 as a
template and/or backbone. Building upon the evidence, we further postulate a
synthetic route for SARS-CoV-2, demonstrating that the laboratory-creation of
this coronavirus is convenient and can be accomplished in approximately six
months. Our work emphasizes the need for an independent investigation into the
relevant research laboratories. It also argues for a critical look into certain
recently published data, which, albeit problematic, was used to support and
claim a natural origin of SARS-CoV-2. From a public health perspective, these
actions are necessary as knowledge of the origin of SARS-CoV-2 and of how the
virus entered the human population are of pivotal importance in the fundamental
control of the COVID-19 pandemic as well as in preventing similar, future pandemics.
https://zenodo.org/record/4028830#.X2DUKWgzZnK
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